The good folks over at CMSWatch report that many content management systems still do not fully support authoring on Vista/IE7.
As they point out in the post, this will be a growing problem for telecommuters as new PCs with Vista are purchased. Most corporations are sticking with XP for now (with good reason) but the home market is another story.
If your staff work on web content from home, you should do some testing with your system on Vista so that you can anticipate any problems and lean on your vendor to get a fix into place if needed.